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Volume 12, Issue 1 (vol-1 2006)                   Intern Med Today 2006, 12(1): 5-10 | Back to browse issues page

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Tayebi-Meybodi N, Amooeian S, Farzadnia M, Memar B, Mahmoudi M, Mozouni M et al . Clinical and laboratory evaluation in 17 cases of macroprolactinemia identified by polyethylene glycol precipitation test. Intern Med Today 2006; 12 (1) :5-10
URL: http://imtj.gmu.ac.ir/article-1-50-en.html
Clinical and laboratory evaluation in 17 cases of macroprolactinemia identified by polyethylene glycol precipitation test
N. Tayebi-Meybodi , S. Amooeian , M. Farzadnia *1 , B. Memar , M. Mahmoudi , M. Mozouni , Z. Erfanian
1- , mhdfarzadnia@yahoo.com
Abstract:   (14410 Views)
Abstract Background and Aim: Macroprolactinemia in which most circulating PRL forms Big Big PRL (>150KD), is a major causes of Idiopathic Hyperprolactinemia with mild or lack of symptoms. We aimed in this study to introduce a simple and inexpensive polyethylene Glycol precipitation test (PEG)for macroprolactin evaluation and avoiding other expensive diagnostic investigations also evaluation of classic hyperprolactinemia symptoms in macroprolactinemic patients Materials and Methods: In this descriptive study, serum prolactin was measured before and after precipitation of macroprolactin by polyethylene glycole in 90 patients with hyperprolactinemia (PRL>30µg/L), furthermore clinical and radiographic findings recorded. Results: 18.8% of cases were macroprolactinemic without hyperprolactinemic classic symptom. Conclusion: Regarding to high prevalence of macroprolactinemia and lack of classic symptoms of hyperprolactinemia and to avoid diagnostic and trapeutic pitfalls the screening for macroprolactin in all hyperprolactinmia recommended.
Keywords: Hyperprolactinemia; Macroprolactin; Polyethylenglycol
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Type of Study: Original | Subject: Internal Medicine
Received: 2007/07/3 | Published: 2006/04/15
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