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Abstract Background and Aim: Macroprolactinemia in which most circulating PRL forms Big Big PRL (>150KD), is a major causes of Idiopathic Hyperprolactinemia with mild or lack of symptoms. We aimed in this study to introduce a simple and inexpensive polyethylene Glycol precipitation test (PEG)for macroprolactin evaluation and avoiding other expensive diagnostic investigations also evaluation of classic hyperprolactinemia symptoms in macroprolactinemic patients Materials and Methods: In this descriptive study, serum prolactin was measured before and after precipitation of macroprolactin by polyethylene glycole in 90 patients with hyperprolactinemia (PRL>30µg/L), furthermore clinical and radiographic findings recorded. Results: 18.8% of cases were macroprolactinemic without hyperprolactinemic classic symptom. Conclusion: Regarding to high prevalence of macroprolactinemia and lack of classic symptoms of hyperprolactinemia and to avoid diagnostic and trapeutic pitfalls the screening for macroprolactin in all hyperprolactinmia recommended.

Keywords: Hyperprolactinemia; Macroprolactin; Polyethylenglycol

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