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Background and Aim: Breast masses are one of the common complaints among women in the world. Among these, breast cancer due to its high prevalence is very important. Three main modalities for the early diagnosis of breast cancer are physical examination, mammography and Fine Needle Aspiration (FNA). The goal of the present study was to evaluate the accuracy of FNA in breast lesions diagnosis. Materials and Methods: In this analytic study, 92 patients with breast mass referred to the surgery clinic at Zahedan Khatam hospital, were randomly selected. At first FNA and the open biopsy methods were carried out. Data were collected based on interview, physical examination, FNA and open biopsy results. Results: According to FNA results, three cysts (3.3%) were diagnosed that were excluded from the study because open biopsy was not carried out on them. Among the remained 89 patients, 7 (7.9%) were inadequate material, 57 (64%) were benign and 25 (28.1%) were malignant. Comparing with the results of open biopsy, FNA had 8 false negative, however there weren't any false positive results. Therefore, sensitivity of FNA was 75.8%, its specificity was 100%, its PPV was 100%, and its NPV was 86%, which were very close to other reports. Accuracy of FNA was 88% which was lower than open biopsy (100%). Conclusion: On the basis of this study, it is concluded that FNA is a very simple, cost effective, and reliable method in differentiating malignant lesions of breast from benign ones. When FNA is positive, it is a particularly suitable substitution for open biopsy. However, when it is negative but the physical signs are indicative of malignancy, it would be better to repeat FNA or to do open biopsy to confirm the diagnosis.

Keywords: Breast mass; FNA; Open biopsy; Breast cancer

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